Anaesthesia for the Patient with Impaired Renal Function

Pharmacokinetics of enfuvirtide in a patient with impaired renal function.

Enfuvirtide is the first member of the fourth class of antiretroviral drugs to become available. We present a case report of a human immunodeficiency virus (HIV)-positive patient with mild renal impairment who developed severe renal impairment secondary to tenofovir therapy while receiving enfuvirtide. Because the patient's pharmacokinetic profile was not significantly altered, compared with th...

Renal function and methoxyflurane anaesthesia.

~IETHOXYFLURANE IS A DIIU(; that is being used with increasing frequency and reports in the literature have suggested that it is sometimes responsible for postoperative renal dysfunction. ~-'; Thus it seemed prudent to consider the available knowledge concerning effects of methoxyflurane on the kidney, in order to decide the manner of drug usage most likely to avoid anv undesirable renal sequel...

Allopurinol in patients with impaired renal function.

Anaesthesia for the patient with cardiac disease.

I have tried to summarize experimental work in human and animal models. This work is complex and difficult to interpret. Clinicians should not take isolated experimental studies and jump to conclusions about clinical use of anaesthetics. Experimenters should not arrive at sweeping conclusions based on a particular experimental study performed under some or other carefully or not so carefully co...

Disposition of [g-h]paclitaxel and Cremophor El in a Patient with Severely Impaired Renal Function

In the present work, we studied the pharmacokinetics and metabolic disposition of [G-H]paclitaxel in a female patient with recurrent ovarian cancer and severe renal impairment (creatinine clearance: ;20 ml/min) due to chronic hypertension and prior cisplatin treatment. During six 3-weekly courses of paclitaxel at a dose level of 157.5 mg/m (viz. a 10% dose reduction), the renal function remaine...